Calmodulin inhibitory activity of the malbrancheamides and various analogs

[摘要] The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified. [GRAPHICS] (C) 2008 Elsevier Ltd. All rights reserved.

[发布日期] 2008-12-15

[关键词] Calmodulin inhibition;Malbrancheamide;Prenylated indole alkaloid