Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging

[摘要] A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4 K) and 2,2',2 '',2'-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After Cu-64 labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation. (c) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-12-15

[关键词] neutrophil antagonist;peptide tracer;inflammation imaging;Cu-64