Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750

[摘要] Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis. (C) 2004 Elsevier Ltd. All rights reserved.

[发布日期] 2004-11-15

[关键词] serotonin;5-HT4;5-HT3;prokinetic;azaadamantane