ONE-POT SYNTHESIS OF CATHEPSIN INHIBITORS - N-ALPHA-PROTECTED N-PEPTIDYL-O-ACETYL HYDROXYLAMINES CATALYZED BY ALCALASE FOLLOWED BY LIPASE IN ANHYDROUS T-BUTANOL

[摘要] N(alpha)-protected N-peptidyl-O-acetyl hydroxylamines [peptide = Ala-ASp(Bzl)-Phe, Pro-Phe-Leu, Ala-Phe, and Pro-Phe] have been synthesized enzymatically in one pot catalyzed by alcalase followed by lipase in t-butanol.

[发布日期] 1992-12-01