Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells

[摘要] Syntheses of eight novel A-ring cleaved oleanane and ursane analogs an described. These compounds were assessed for their ability to inhibit cell proliferation in NRP.152 prostate cells. Four A-ring cleaved derivatives showed significant activity; 5 beta-(1-methyl-2-ethyl)-10 alpha-(3-aminopropyl)-des-A-urs-12-en-28-oic acid was the most active compound, (IC50, 0.3 mu M). (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-07-08