Synthesis and evaluation of novel heterocyclic MMP inhibitors

[摘要] A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered. (c) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-12-15

[关键词] matrix metalloproteinase inhibitors;pyridinones;bis-heterocycles