Peptide-binding antibiotics:: A solid-phase assay for screening libraries of vancomycin mimics for selective d-Ala-d-Ala binding

[摘要] Due to recent increases of vancomycin-resistant bacterial infections, research on more effective antibiotics has intensified, As part of such research, screening of combinatorial libraries is a valuable approach for discovering new lead antibiotics, A screening method is presented here that uses a solid state library and a fluorescent label to detect RCO-d-Ala-d-Ala binding in aqueous media. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-12-16