Synthesis of novel taxol analogs and evaluation of their biological activities

[摘要] Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was similar to 60-fold less active and 10 was similar to 15-fold less active. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-07-22