Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
[摘要] Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site mGlu(5) PAM chemotype. (C) 2012 Elsevier Ltd. All rights reserved.
[发布日期] 2012-12-15 [发布机构]
[效力级别] [学科分类]
[关键词] Metabotropic glutamate receptor 5 (mGlu(5));Positive allosteric modulator (PAM);Non-MPEP [时效性]
