A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane

[摘要] A novel photoaffinity label for the dopamine transporter (DAT) based on N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane has been synthesized in five steps and has been characterized. Preliminary binding studies indicated this ligand bound irreversibly to the dopamine transporter. Preparation of the I-125 analog and its photoactivation in the presence of membrane bound DAT demonstrated it covalently binds to the DAT. Published by Elsevier Science Ltd.

[发布日期] 1997-12-02