Dynamics of a cell motility model near the sharp interface limit

[摘要] Phase-field models have recently had great success in describing the dynamic morphologies and motility of eukaryotic cells. In this work we investigate the minimal phase-field model introduced in Berlyand et al. (2017). Rigorous analysis of its sharp interface limit dynamics was completed in Mizuhara et al., 2016, Mizuhara et al., 2019, where it was observed that persistent cell motion was not stable. In this work we numerically study the pre-limiting phase-field model near the sharp interface limit, to better understand this lack of persistent motion. We find that immobile, persistent, and rotating states are all exhibited in this minimal model, and investigate the loss of persistent motion in the sharp interface limit. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-11-21

[关键词] Phase-field;Keratocyte motion;Traveling wave;Rotating cell