A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in Chinese

[摘要] Parkinson's disease (PD) is a complex neurodegenerative disease with genetic risk factors. Common variants in genes implicated in hereditary forms of parkinsonism may be predisposing factors for sporadic PD. Recent studies have demonstrated that mutations in PINK1 (PARK6 locus) gene, encoding PTEN-induced kinase 1, are associated with both familial recessive and sporadic early onset parkinsonism. In order to assess whether the coding variant A340T contributes to the risk of late-onset PD, we performed an association study of 539 PD patients with an onset age at or older than 50 and 525 controls in Chinese Han. Genotyping was performed by denaturing high performance liquid chromatography (DHPLC) combined with sequencing analyses. The A-allele frequency was 6.2% in PD and 4.2% in controls (p = 0.0404), while G/A genotype frequencies were 12.4% in PD and 8.4% in the controls (p = 0.0350). Our results yielded significant evidence for disease association between PINK1 A340T and PD with later onset (OR 1.55, 95% CI 1.04-2.32, p = 0.0393), thus suggesting that PINK1 A340T variant may contribute to the risk for late-onset PD in Chinese. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

[发布日期] 2006-12-20

[关键词] Parkinson's disease;PINK1;genetic susceptibility;single nucleotide polymorphism;rs3738136