FORMATION OF INOSITOL PHOSPHATES MEDIATED BY M(3) MUSCARINIC RECEPTORS IN TYPE-1 AND TYPE-2 ASTROCYTES FROM NEONATAL RAT CEREBRAL-CORTEX

[摘要] Muscarinic receptor subtype in type-1 and type-2 astrocytes from rat neonalal cerebral cortex was examined for carbachol-elicited inositol phosphate (IF) formation. The formation of carbachol-elicited IP was inhibited by various muscarinic antagonists in the following relative order of potency: 4-DAMP greater than or equal to atropine much greater than pirenzepine > AF-DX 116. This pharmacological profile suggests that the activation of the M(3) muscarinic receptor subtype is responsible for the stimulation of IP formation in both astrocytes.

[发布日期] 1994-10-24

[关键词] ASTROCYTE;INOSITOL PHOSPHATE;CARBACHOL;MUSCARINIC RECEPTOR;RECEPTOR SUBTYPE;MUSCARINIC ANTAGONIST