Does the gut microbiota contribute to the oligodendrocyte progenitor niche?

[摘要] The past decade has seen a growing number of studies on the relationship between the gut microbiota and the brain. This mini-review will focus on the unexpected findings linking the microbiome to myelination. We first address the temporal correlation between the acquisition of a gut microbiota in the developing organism and developmental myelination. We then review the factors impacting the composition of the child's gut microbiota, ranging from maternal stress to modality of delivery and from breastfeeding and diet composition to antibiotic treatment early in life. We discuss the topic of gut-brain communication with an emphasis on myelination, and propose the concept that gut microbes produce metabolites which may constitute a metabolic niche. Distinct bacterial communities may create very different niches, some permissive and others inhibitory for myelin generation or maintenance. We speculate that this concept of gut dysbiosis may also in part explain the reduced myelin content detected in several neurological and psychiatric disorders. We conclude by envisioning intervention with probiotics and prebiotics to favor the formation of a microbial metabolic niche favoring myelin production to promote brain health.

[发布日期] 2020-01-10

[关键词] Microbiome;Oligodendrocyte;Development;Myelination;Brain