ABNORMAL ENDOGENOUS AMINO-ACID RELEASE IN BRAIN-SLICES FROM VITAMIN-B6 RESTRICTED NEONATAL RATS

[摘要] The basal and potassium-evoked efflux of glutamate, glycine, taurine, and gamma-aminobutyric acid (GABA) was measured in brain slices from vitamin B-6 restricted and sufficient 14-day-old rats. The results indicate a reduced level of basal glutamate, taurine, and GABA efflux in hippocampal slices and taurine and GABA in cortical slices from vitamin B-6 restricted animals. In the presence of depolarizing potassium concentrations, there was a reduced level of GABA efflux in hippocampal and cortical slices, and a marked reduction in the release of glutamate in cortical slices from B-6 restricted rats. The abnormalities in the secretion process of these neuroactive amino acids may be related to the neurological sequelae associated with neonatal vitamin B-6 restriction.

[发布日期] 1991-01-02

[关键词] BRAIN SLICE;HIPPOCAMPUS;CORTEX;AMINO ACID;VITAMIN-B6 DEFICIENCY;NEONATAL;RAT