GABA(A) RECEPTOR BETA(1-3) SUBUNIT GENE-EXPRESSION IN THE HIPPOCAMPUS OF KINDLED RATS

[摘要] The effect of Schaffer collateral/commissural fiber kindling on the expression levels of GABA(A) receptor beta(1), beta(2), and beta(3) subunit mRNA in the pyramidal and granular neurons of the rat dorsal hippocampus was studied, using semi-quantitative in situ hybridization. In pyramidal neurons of CA1 and CA3, only small changes (10-15%) were found. In dentate granule neurons, the expression level of GABA(A)R-beta(3) mRNA was significantly, enhanced, bilaterally, in animals that were partial or fully kindled. At long-term, 4 weeks after the last convulsion no significant changes were found in pyramidal or granular neurons.

[发布日期] 1994-06-06

[关键词] KINDLING;GABA(A) RECEPTOR BETA SUBUNIT;GAMMA-AMINOBUTYRIC ACID;MESSENGER-RNA;HYBRIDIZATION;IN SITU HIPPOCAMPUS;FASCIA DENTATA;EPILEPTOGENESIS