TRP channels in disease

[摘要] Transient receptor potential cation channels (TRP channels) play a unique role as cell sensors, are involved in a plethora of Ca 2+-mediated cell functions, and play a role as gate-keepers in many homeostatic processes such as Ca2+ and Mg2+ reabsorption. The variety of functions to which TRP channels contribute and the polymodal character of their activation predict that failures in correct channel gating or permeation will likely contribute to complex pathophysio logical mechanisms. Dysfunctions of TRPs cause human diseases but are also involved in a complex manner to contribute and determine the progress of several diseases. Contributions to this special issue discuss channelopathias for which mutations in TRP channels that induce loss- or gain-of-function of the channel and can be considered disease-causing have been identified. The role of TRPs will be further elucidated in complex diseases of the intestinal, renal, urogenital, respiratory, and cardiovascular systems. Finally, the role of TRPs will be discussed in neuronal diseases and neurodegenerative disorders. (c) 2007 Elsevier B.V All rights reserved.

[发布日期] 2007-08-01

[关键词] TRP channel;channelopathy;hereditary disease;systemic disease;transgenic model