sAC from aquatic organisms as a model to study the evolution of acid/base sensing

[摘要] Soluble adenylyl cyclase (sAC) is poised to play multiple physiological roles as an acid/base (A/B) sensor in aquatic organisms. Many of these roles are probably similar to those in mammals; a striking example is the evolutionary conservation of a mechanism involving sAC, carbonic anhydrase and vacuolar H+-ATPase that acts as a sensor system and regulator of extracellular A/B in shark gills and mammalian epididymis and kidney. Additionally, the aquatic environment presents unique A/B and physiological challenges; therefore, sACs from aquatic organisms have likely evolved distinct kinetic properties as well as distinct physiological roles, sACs from aquatic organisms offer an excellent opportunity for studying the evolution of A/B sensing at both the molecular and whole organism levels. Moreover, this information could help understand and predict organismal responses to environmental stress based on mechanistic models. This article is part of a Special Issue entitled The Role of Soluble Adenylyl Cyclase in Health and Disease, guest edited by J. Buck and L. R. Levin. (C) 2014 Elsevier B.V. All rights reserved.

[发布日期] 2014-12-01

[关键词] Cyclic AMP;Bicarbonate;Acidosis;Alkalosis;Cell signaling;Carbon Dioxide