Synthesis of substituted 2-phenylhistamines via a microwave promoted Suzuki coupling

[摘要] Substitutions on the 2-position of the imidazole ring of histamine have proven useful in a number of biochemical settings. Current art for the synthesis of these constructs relies upon a cumbersome and low-yielding condensation reaction. Here-in we report a new procedure for the synthesis of a series of substituted 2-phenylhistamines utilizing a microwave-promoted Suzuki coupling. Published by Elsevier Ltd.

[发布日期] 2007-12-24