Application of chiral (E)-crotylsilanes in synthesis: The asymmetric synthesis of the C19-C34 spiroketal fragment of rutamycin B.

[摘要] The asymmetric synthesis of the spiroketal fragment of rutamycin B is reported employing allylsilane bond construction methodology for the introduction of five of the eight stereogenic centers. In this paper, the construction of the C19-C28 and C29-C34 fragments as well as their coupling through an alkylation reaction of a lithiated N,N-dimethylhydrazone are described. (C) 1997 Published by Elsevier Science Ltd.

[发布日期] 1997-02-24