STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF TETRONOLIDE .2. A STEREOSELECTIVE ROUTE TO THE RACEMIC CYCLOHEXENE SUBUNIT

[摘要] A short stereoselective sequence is described for the preparation of the racemic form of the highly functionalized cyclohexene derivative 2 which comprises the upper segment of tetronolide (1), the aglycone of the antitumor tetrocarcins. A key element of this route is the rapid assembly and intramolecular cycloaddition of the trienyl enol pyruvate 4, which achieves complete control over regiochemistry and good stereochemical control.

[发布日期] 1991-08-12