A short synthesis of an important precursor to a new class of bicyclic beta-lactamase inhibitors

[摘要] A short synthesis of an important precursor to known bicyclic beta-lactamase inhibitors is described. The synthesis uses commercially available trans-3-hydroxy-L-proline 1. Protection of the amino group followed by formation of the hydroxamate and cyclization using Mitsunobu conditions afforded bicyclic beta-lactam 4 in three steps in 53% overall yield. Copyright (C) 1996 Elsevier Science Ltd

[发布日期] 1997-01-13