Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function

[摘要] Linoleate triol esters are intermediates along the pathway of formation of the mammalian skin permeability barrier. In connection with the study of their involvement in barrier formation we required access to isomerically pure and defined samples of four linoleate triol esters. A common synthetic strategy was developed starting from isomeric alkynols derived from D-tartaric acid and 2-deoxy-D-ribose. (C) 2018 Published by Elsevier Ltd.

[发布日期] 2018-12-26

[关键词] Total synthesis;Stereochemistry;Fatty acids;Synthesis strategy