Synthesis of retro-inverso peptides employing isocyanates of Nα-Fmoc-amino acids/peptide acids catalyzed by DMAP

[摘要] The Goldschmidt-Wick type reaction between isocyanates of N-alpha-Fmoc-amino acids/peptide acids and N-alpha-Boc-/Z-/ Bsmoc-amino acids catalyzed by DMAP leads to the incorporation of a reversed peptide bond. It was found to be a simple, efficient and clean reaction. All the retro-inverso peptides made were obtained as crystalline compounds in 70-92% yields. (c) 2006 Elsevier Ltd. All rights reserved.

[发布日期] 2006-12-18

[效力级别]  Proceedings Paper