A chemoselective rhodium(II) mediated solid phase 1,3-dipolar cycloaddition and its application to a thermally self-cleaving furan scaffold

[摘要] A chemoselective rhodium(II) mediated 1,3-dipolar cycloaddition reaction on solid-phase for the construction of a template-directed scaffold is described. In this paper, the reaction of acetylenes with isomunchnones is presented as a general methodology for the combinatorial formation of a furan based library. Additionally, through the development of a novel thermolytic cleavage step, this furan synthesis yields pure product from the solid-phase in a temperature dependent manner. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-10-13