SYNTHESIS OF A DISULFIDE CROSS-LINKED DNA TRIPLE-HELIX

[摘要] An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

[发布日期] 1994-06-27

[关键词] DISULFIDE CROSS-LINK;DNA TRIPLE HELIX