A Tamao-Fleming oxidation route to dipeptides bearing N,O-acetal functionality

[摘要] Tamao-Fleming oxidation of the N-dimethylphenylsilylmethyl group linked to the nitrogen of a peptide bond enables access to dipeptide N,O-acetal functionality. The N-silylmethyl functionality serves as a latent form of the N,O-acetal which is revealed after peptide bond construction. (C) 2017 Published by Elsevier Ltd.

[发布日期] 2017-12-27

[关键词] Peptides;Oxidation reactions;N,O-Acetals;Prodrugs;Bioconjugate chemistry