Synthetic studies of microtubule stabilizing agent peloruside A:: an asymmetric synthesis of C10-C24 segment

[摘要] An asymmetric synthesis of the C-10-C-24 fragment of the potent antitumor macrolide, peloruside A is described. All three stereogenic centers have been enantioselectively constructed utilizing Evans alkylation, Brown asymmetric allylboration, and a substrate controlled epoxide formation. Other key reactions involved Grubbs's ring-closing olefin metathesis and Ando's Z-selective olefination reaction. (C) 2003 Elsevier Ltd. All rights reserved.

[发布日期] 2003-10-06