LIPASE MEDIATED RESOLUTION OF CHIRAL (E)-VINYLSILANES - AN IMPROVED PROCEDURE FOR THE PRODUCTION OF (R)-(E)-1-TRIALKYLSILYL-1-BUTEN-3-OL AND (S)-(E)-1-TRIALKYLSILYL-1-BUTEN-3-OL DERIVATIVES

[摘要] A crude enzymic extract of Pseudomonas AK in pentane catalyzes the transesterification of chiral (E)-vinylsilanes 1, resulting in the production of highly enantiomerically enriched (R)- and (S)-(E)-1-trialkylsilyl-1-buten-3-ol derivatives (S)-2 and (R)-3. A series of related vinylsilanes and two-different lipases have been screened to identify optimal reaction conditions.

[发布日期] 1991-08-12