Modern synthesis of carbamoyl fluorides

[摘要] This digest article summarizes the recent advances made for the synthesis of carbamoyl fluoride derivatives. Herein are highlighted several efficient methodologies. The scope of amine starting material encompasses hydroxylamines, isothiocyanates as well as secondary amines. The main strategies toward efficient methods to access carbamoyl fluorides are based on the in situ formation of difluorophosgene or the use of carbon dioxide in conjunction with deoxyfluorination reagents. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-11-19

[关键词] Fluorine;Carbamoyl fluorides;Difluorocarbenes;Difluorophosgene;Deoxyfluorination