Double stereodifferentiating crotylation reactions with alpha-amino aldehydes: Asymmetric synthesis of vicinal amino alcohol synthons

[摘要] The sense and level of 1,2-asymmetric induction have been evaluated in the BF3 . OEt2 promoted addition of (E)-crotylsilanes (R)-1 and (S)-1 to alpha-amino aldehydes 2a through 2d. The sense of carbonyl diastereoface selectivity was shown to be dependent of the chirality of the silane reagent. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-07-21