OLEFIN OXIDATIVE CLEAVAGE AND DIOXETANE FORMATION USING TRIETHYLSILYL HYDROTRIOXIDE - APPLICATIONS TO PREPARATION OF POTENT ANTIMALARIAL 1,2,4-TRIOXANES

[摘要] Oxidative cleavage of alkenyl esters and ethers using Et3SiOOOH was found to be easier than oxidative cleavage of hydrocarbon alkenes, and Et3SiOOOH was successfully applied to very short syntheses of new, simple, and potent antimalarial trioxanes 6 and 8.

[发布日期] 1991-08-19