Studies towards the synthesis of the marine metabolite, octalactin A

[摘要] Studies towards the synthesis of the marine metabolite octalactin A 1, are described. Key steps in this strategy include an anti aldol reaction to set the C-7-C-8 stereochemistry, Homer Wadsworth Emmons coupling to give the trisubstituted E-double bond and a novel samarium-mediated cyclisation reaction. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-11-24