Total synthesis of variolin B

[摘要] The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. (C) 2001 Elsevier Science Ltd. All rights reserved.

[发布日期] 2001-12-03