Chemoselective addition of Grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: Synthesis of 4-oxo and homologous esters

[摘要] A method for the synthesis of Core and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with lequiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-03-10