A NOVEL INHIBITOR OF HUMAN ALPHA-L-FUCOSIDASE - ENANTIOSELECTIVE SYNTHESIS OF L-FUCOAMIDRAZONE

[摘要] A short, chiral synthesis of the title inhibitor 1 is reported from D-galactosamine by chain end interchange. The L-fucoamidrazone is a good competitive inhibitor of human alpha-L-fucosidase (K-i = 820 nM).

[发布日期] 1994-06-06