CYCLOOLIGOMERIC RECEPTORS FOR THE SEQUENCE SELECTIVE BINDING OF PEPTIDES - A TETRAHEDRAL RECEPTOR FROM TRIMESIC ACID AND 1,2-DIAMINES

[摘要] The first members of a new family of tetrahedral receptors (2) have been prepared from trimesic acid and certain chiral 1,2-diamines. A survey of the binding properties of one of these with a 50,000-member peptide library finds high selectivity for N-acetylated terminal residues (particularly Ac-(D)Gln) and the dipeptide sequence (L)Gln-(L)Pro.

[发布日期] 1994-11-14