ASYMMETRIC OXIDATION OF BETA-KETOESTERS WITH BENZOYL PEROXIDE - ENANTIOSELECTIVE FORMATION OF PROTECTED TERTIARY ALCOHOLS

[摘要] Asymmetric oxidation of beta-ketoesters by the benzoyl peroxide quench of their lithioenamines formed with (S)-valine t-butyl esters has been accomplished with good enantioselectivity for the formation of tertiary benzoate esters. This procedure thus enables generation of tertiary alcohols in protected form.

[发布日期] 1991-10-14

[关键词] BETA-KETOESTER OXIDATION;ASYMMETRIC ENOLATE OXIDATION;BENZOYL PEROXIDE;LITHIOENAMINE