Synthesis of 1H-pyrazolo[3,4-d]pyrimidines via solid-phase Aza-Wittig/electrocyclic ring closure reaction
[摘要] An elegant solid-phase synthetic route of pyrazolo[3,4-d]pyrimidine derivatives via Aza-Wittig/electrocyclic ring closure reaction was developed and validated. By manipulating the R group from the primary amine building block, one can easily prepare the library of pyrazolo[3,4-d]pyrimidine derivatives. (C) 2013 Elsevier Ltd. All rights reserved.
[发布日期] 2013-12-11 [发布机构]
[效力级别] [学科分类]
[关键词] Solid-phase synthesis;Combinatorial chemistry;Aza-Wittig reaction;Electrocyclization ring closure;Heterocyclic;Pyrazolo[3,4-d]pyrimidine [时效性]
