Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

[摘要] First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

[发布日期] 2010-12-08