SbCl5-wet acetonitrile:: a new system for chemoselective O-desilylation

[摘要] A new efficient method for deprotection of TBDMS derivatives of phenols, primary alcohols, carboxylic acids and secondary amines, consisting of SbCl5 and MeCN with 0.1% water (w/v), is reported. It effects inter alia desilylation of a CH2OTBDMS group in the presence of a ketal function. (C) 2003 Elsevier Ltd. All rights reserved.

[发布日期] 2003-12-01