Application of a novel directing effect in an organocopper/orthoester reaction to the synthesis of deuterium labeled unsaturated esters

[摘要] Deuterium labeled methacrylates (5,6), tiglates (10,12), and senecioates (13,14,16,17), important for biosynthetic studies on the synthesis of carboxylic acids in carabid beetles, have been prepared using organocopper-alkyne coupling reactions. With 1,1,1-triethoxypropyne as a coupling partner, a novel directing effect was observed; the ''branched'' product was formed exclusively. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-09-29