Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans

[摘要] The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-12-03

[关键词] Hyphal formation;Candida albicans;Benzophenone;Daldinia spp