SOLID-PHASE SYNTHESIS OF PEPTIDES USING ALLYLIC ANCHORING GROUPS .2. PALLADIUM-CATALYZED CLEAVAGE OF FMOC-PROTECTED PEPTIDES

[摘要] High yields for the cleavage reaction of Fmoc-protected peptide segments from an allylic handle may be obtained using tributyltin hydride in the presence of (Ph(3)P)PdCl2 in a 1:1 mixture of DMF/DCM. Alternatively the cleavage reaction may be carried out using NMA as nucleophile in a 2:2:1 mixture of DMSO/THF/0.5M HCl in the presence of (Ph(3)P)(4)Pd. The Fmoc group is completely stable to both these cleavage methods.

[发布日期] 1994-06-20