Synthetic studies of antitumor macrolide laulimalide: Enantioselective synthesis of the C-3-C-14 segment by a catalytic hetero Diels-Alder strategy

[摘要] The C-3-C-14 segment of the novel antitumor agent laulimalide has been constructed enantioselectively by utilizing a catalytic asymmetric hetero Diels-Alder reaction of benzyloxyacetaldehyde and Danishefsky's diene followed by Ferrier rearrangement and asymmetric conjugate reaction as the key steps. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-04-07