SYNTHESIS OF A PYRIDO[1,2-A]PURINE NUCLEOSIDE BY A NOVEL RING CLEAVAGE-ANNULATION REACTION OF 3-BETA-D-RIBOFURANOSYLIMIDAZO[4,5-D]-VIC-TRIAZIN-4-ONE

[摘要] Treatment of 7-(2,3,5-tris-O-(t-butyldimethylsilyl)-beta-D-ribofuranosyl)imidazo[4,5-d]-v-triazin-4-one (1) with MnO2 in hot pyridine furnished 7-(2,3,5-tris-O-(t-butyldimethylsilyl)-beta-D-ribofuranosyl)pyrido[1,2-a]-purine (4). Treatment of 4 with tetra-n-butylammonium fluoride furnished the free nucleoside 5.

[发布日期] 1991-10-07