Synthesis of a dinucleating ligand with addressed ion binding sites

[摘要] A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Angstrom apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-06-23