SYNTHESIS OF GAMMA-METHOXY CARBOXYLIC-ACIDS VIA NUCLEOPHILIC ADDITIONS TO OXYCARBENIUM IONS DERIVED FROM 5-METHOXY-2(3H)-DIHYDROFURANONES

[摘要] The Lewis acid induced addition of silylated nucleophiles to 5-methoxy-2(3H)-dihydrofuranones was studied. The methodology gives access to alpha,beta-substituted-gamma-alkoxy carboxylic acids with modest to high levels of acyclic diastereocontrol in the addition reaction

[发布日期] 1994-11-07