Spongistatin synthetic studies .1. Construction of a C(29-48) subtarget

[摘要] In this Letter, the first in a series of three, we outline our overall strategy and describe the assembly of a C(29-48) EF-ring advanced intermediate for the total synthesis of the spongistatins, rare and structurally unique polyether macrolides with unprecedented antitumor activity. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-12-15