Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

[摘要] Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. The coupling is reasonably fast, clean, racemization free and high yielding. (C) 1998 Elsevier Science Ltd. All rights reserved.

[发布日期] 1998-12-24